Adreview

Drug overview for ADREVIEW (iobenguane sulfate i-123):

Generic name: IOBENGUANE SULFATE I-123
Drug class:
Therapeutic class: Diagnostic Agents

No enhanced Introduction information available for this drug.

No enhanced Uses information available for this drug.

DRUG IMAGES

No Image Available

The following indications for ADREVIEW (iobenguane sulfate i-123) have been approved by the FDA:

Indications:
Diagnostic imaging

Professional Synonyms:
Diagnostic imaging exam
Diagnostic imaging procedure
Diagnostic radiography
Diagnostic radiology

The following drug interaction information is available for ADREVIEW (iobenguane sulfate i-123):

Contraindicated
Severe
Moderate

There are 0 contraindications.

There are 2 severe interactions. These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.

Drug Interaction	Drug Names
Radioactive Iodide/Agents that Affect Iodide SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Many compounds can affect iodide protein binding and alter iodide pharmacokinetics and pharmacodynamics.(1) CLINICAL EFFECTS: Compounds that affect iodide pharmacokinetics and pharmacodynamics may impact the effectiveness of radioactive iodide.(1) PREDISPOSING FACTORS: Compounds that affect iodide pharmacokinetics and pharmacodynamics are expected to have the most impact during therapy using radioactive iodide. Diagnostic procedures would be expected to be impacted less. PATIENT MANAGEMENT: Discuss the use of agents that affect iodide pharmacokinetics and pharmacodynamics with the patient's oncologist.(1) Because indocyanine green contains sodium iodide, the iodine-binding capacity of thyroid tissue may be reduced for at least one week following administration. Do not perform radioactive iodine uptake studies for at least one week following administration of indocyanine green.(2) The manufacturer of iopamidol states administration may interfere with thyroid uptake of radioactive iodine and decrease therapeutic and diagnostic efficacy. Avoid thyroid therapy or testing for up to 6 weeks post administration of iopamidol.(3) DISCUSSION: Many agents interact with radioactive iodine. The average duration of effect is: anticoagulants - 1 week antihistamines - 1 week anti-thyroid drugs, e.g: carbimazole, methimazole, propylthiouracil - 3-5 days corticosteroids - 1 week iodide-containing medications, e.g: amiodarone - 1-6 months expectorants - 2 weeks Lugol solution - 3 weeks saturated solution of potassium iodine - 3 weeks vitamins - 10-14 days iodide-containing X-ray contrast agents - up to 1 year lithium - 4 weeks phenylbutazone - 1-2 weeks sulfonamides - 1 week thyroid hormones (natural or synthetic), e.g.: thyroxine - 4 weeks tri-iodothyronine - 2 weeks tolbutamide - 1 week topical iodide - 1-9 months (1)	ADDAMEL N, ADTHYZA, ADVAIR DISKUS, ADVAIR HFA, AGAMREE, AIRDUO DIGIHALER, AIRDUO RESPICLICK, AIRSUPRA, ALKINDI SPRINKLE, ALVESCO, AMIODARONE HCL, AMIODARONE HCL-D5W, ARMONAIR DIGIHALER, ARMOUR THYROID, ARNUITY ELLIPTA, ASMANEX, ASMANEX HFA, AZELASTINE HCL, AZELASTINE-FLUTICASONE, AZULFIDINE, BACTRIM, BACTRIM DS, BECLOMETHASONE DIPROPIONATE, BETA 1, BETALOAN SUIK, BETAMETHASONE ACETATE MICRO, BETAMETHASONE ACETATE-SOD PHOS, BETAMETHASONE DIPROPIONATE, BETAMETHASONE SOD PHOS-ACETATE, BETAMETHASONE SOD PHOS-WATER, BETAMETHASONE SODIUM PHOSPHATE, BETAMETHASONE VALERATE, BREO ELLIPTA, BREYNA, BREZTRI AEROSPHERE, BROMFED DM, BROMPHENIRAMINE MALEATE, BROMPHENIRAMINE-PSEUDOEPHED-DM, BSP 0820, BUDESONIDE, BUDESONIDE DR, BUDESONIDE EC, BUDESONIDE ER, BUDESONIDE MICRONIZED, BUDESONIDE-FORMOTEROL FUMARATE, BUPIVACAINE-DEXAMETH-EPINEPHRN, CARBINOXAMINE MALEATE, CARBINOXAMINE MALEATE ER, CELESTONE, CETIRIZINE HCL, CHLORPHENIRAMINE MALEATE, CLARINEX, CLARINEX-D 12 HOUR, CLEMASTINE FUMARATE, CLEMASZ, CLIOQUINOL, CLOBETASOL PROPIONATE MICRO, CONRAY, CONRAY-30, CONRAY-43, CORTEF, CORTISONE ACETATE, CYPROHEPTADINE HCL, CYTOMEL, DATSCAN, DEFLAZACORT, DEPO-MEDROL, DESLORATADINE, DESONIDE MICRONIZED, DESOXIMETASONE, DEXABLISS, DEXAMETHASONE, DEXAMETHASONE ACETATE, DEXAMETHASONE ACETATE MICRO, DEXAMETHASONE INTENSOL, DEXAMETHASONE ISONICOTINATE, DEXAMETHASONE MICRONIZED, DEXAMETHASONE SOD PHOS-WATER, DEXAMETHASONE SODIUM PHOSPHATE, DEXAMETHASONE-0.9% NACL, DEXCHLORPHENIRAMINE MALEATE, DIATRIZOATE MEGLUMINE-SODIUM, DICLEGIS, DIPHEN, DIPHENHYDRAMINE HCL, DIPHENHYDRAMINE-0.9% NACL, DMT SUIK, DOUBLEDEX, DOXYLAMINE SUCC-PYRIDOXINE HCL, DULERA, DYMISTA, EMFLAZA, EOHILIA, ERMEZA, EUTHYROX, FEXOFENADINE HCL, FLUNISOLIDE, FLUOCINOLONE ACETONIDE, FLUOCINOLONE ACETONIDE MICRO, FLUOCINONIDE MICRONIZED, FLUTICASONE PROPIONATE, FLUTICASONE PROPIONATE HFA, FLUTICASONE PROPIONATE MICRO, FLUTICASONE-SALMETEROL, FLUTICASONE-SALMETEROL HFA, FLUTICASONE-VILANTEROL, GASTROGRAFIN, HEMADY, HEXATRIONE, HYDROCODONE-CHLORPHENIRAMNE ER, HYDROCORTISONE, HYDROCORTISONE SOD SUCCINATE, HYDROXYZINE HCL, HYDROXYZINE PAMOATE, IBUPROFEN-FAMOTIDINE, IC GREEN, IDOXURIDINE, INDOCYANINE GREEN, IODINE, IODIXANOL, IODOFORM, IODOPEN, IODOQUINOL, IOFLUPANE I-123, IOMERON 350, IOPAMIDOL, IOPANOIC ACID, ISOPROPAMIDE IODIDE, ISOVUE-200, ISOVUE-250, ISOVUE-300, ISOVUE-370, JANTOVEN, KARBINAL ER, KENALOG-10, KENALOG-40, KENALOG-80, LEVO-T, LEVOCETIRIZINE DIHYDROCHLORIDE, LEVOTHYROXINE SODIUM, LEVOXYL, LIDOCIDEX-I, LIOTHYRONINE SODIUM, LIPIODOL, LITHIUM CARBONATE, LITHIUM CARBONATE ER, LITHIUM CITRATE, LITHIUM CITRATE TETRAHYDRATE, LITHOBID, LORATADINE, LORATADINE MICRONIZED, LUGOL'S, MAS CARE-PAK, MD-GASTROVIEW, MEDROL, MEDROLOAN II SUIK, MEDROLOAN SUIK, METHIMAZOLE, METHYLPREDNISOLONE, METHYLPREDNISOLONE AC MICRO, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCC, MILLIPRED, MILLIPRED DP, MOMETASONE FUROATE, NEXTERONE, NIVA THYROID, NP THYROID, OLOPATADINE HCL, OMNARIS, OMNIPAQUE, OPTIRAY 240, OPTIRAY 300, OPTIRAY 320, OPTIRAY 350, ORAPRED ODT, ORTIKOS, OXILAN-350, PACERONE, PEDIAPRED, PEDITRACE, PHENERGAN, PHENIRAMINE MALEATE, PHENYLBUTAZONE, POTASSIUM IODIDE, POVIDONE IODINE, PREDNISOLONE, PREDNISOLONE SODIUM PHOS ODT, PREDNISOLONE SODIUM PHOSPHATE, PREDNISONE, PREDNISONE INTENSOL, PRO-C-DURE 5, PRO-C-DURE 6, PROMETHAZINE HCL, PROMETHAZINE HCL-0.9% NACL, PROMETHAZINE VC, PROMETHAZINE-CODEINE, PROMETHAZINE-DM, PROMETHAZINE-PHENYLEPHRINE HCL, PROPYLTHIOURACIL, PS1 ACIURGY PACK, PS2 ACIURGY PACK, PULMICORT, PULMICORT FLEXHALER, PYRILAMINE MALEATE, QNASL, QNASL CHILDREN, QUZYTTIR, QVAR REDIHALER, RAYOS, RENTHYROID, RESPA A.R., RYALTRIS, RYCLORA, RYVENT, SINOGRAFIN, SINUVA, SOLU-CORTEF, SOLU-MEDROL, SPY AGENT GREEN, SPY-MIS, SSKI, STRONG IODINE, SULFADIAZINE, SULFAMETHOXAZOLE-TRIMETHOPRIM, SULFASALAZINE, SULFASALAZINE DR, SULFATRIM, SYMBICORT, SYNTHROID, TAPERDEX, TARPEYO, THYMOL IODIDE, THYQUIDITY, THYROID, TICANASE, TIROSINT, TIROSINT-SOL, TRELEGY ELLIPTA, TRIAMCINOLONE, TRIAMCINOLONE ACETONIDE, TRIAMCINOLONE DIACETATE, TRIAMCINOLONE DIACETATE MICRO, TRILOAN II SUIK, TRILOAN SUIK, TUXARIN ER, UCERIS, ULTRAVIST, UNITHROID, VERIPRED 20, VISIPAQUE, WARFARIN SODIUM, WIXELA INHUB, XHANCE, ZCORT, ZETONNA, ZILRETTA
Iobenguane I 123/Agents that Affect Catecholamines SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Many compounds that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells.(1) CLINICAL EFFECTS: Compounds that reduce catecholamine uptake or that deplete catecholamine stores may interfere with imaging completed with iobenguane.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Discuss the use of agents that affect catecholamines. Discontinue drugs that reduce catecholamine uptake or deplete catecholamine stores prior to imaging with iobenguane. Before imaging with iobenguane, discontinue agents that affect catecholamines for at least 5 biological half-lives, as clinically tolerated.(1) DISCUSSION: Many agents may reduce catecholamine uptake or deplete catecholamine stores.(1) Examples include: - CNS stimulants or amphetamines (e.g. cocaine, methylphenidate, dextroamphetamine) - norepinephrine and dopamine reuptake inhibitors (e.g. phentermine) - norepinephrine and serotonin reuptake inhibitors (e.g. tramadol) - monoamine oxidase inhibitors (e.g. phenelzine, linezolid) - central monoamine depleting drugs (e.g. reserpine) - non-select beta adrenergic blocking drugs (e.g. labetalol) - alpha agonists or alpha/beta agonists (e.g. pseudoephedrine, phenylephrine, ephedrine, phenylpropanolamine, naphazoline) - tricyclic antidepressants or norepinephrine reuptake inhibitors (e.g. amitriptyline, bupropion, duloxetine, mirtazapine, venlafaxine) - botanicals that may inhibit reuptake of norepinephrine, serotonin or dopamine (e.g. ephedra, ma huang, St. John's Wort, yohimbine)	ADDERALL, ADDERALL XR, ADIPEX-P, ADRENALIN, ADVAIR DISKUS, ADVAIR HFA, ADZENYS XR-ODT, AIRDUO DIGIHALER, AIRDUO RESPICLICK, AIRSUPRA, AKOVAZ, ALBUTEROL SULFATE, ALBUTEROL SULFATE HFA, AMITRIPTYLINE HCL, AMOXAPINE, AMPHETAMINE SULFATE, AMRIX, ANAFRANIL, ANORO ELLIPTA, APLENZIN, APTENSIO XR, ARFORMOTEROL TARTRATE, ARTICADENT DENTAL, ARTICAINE-EPINEPHRINE, ARTICAINE-EPINEPHRINE BIT, AUSTEDO, AUSTEDO XR, AUSTEDO XR TITRATION KT(WK1-4), AUVELITY, AZILECT, AZSTARYS, BENACTYZINE HCL, BENZPHETAMINE HCL, BETAPACE, BETAPACE AF, BETIMOL, BEVESPI AEROSPHERE, BIORPHEN, BREO ELLIPTA, BREYNA, BREZTRI AEROSPHERE, BRIMONIDINE TARTRATE-TIMOLOL, BROMFED DM, BROMPHENIRAMINE-PSEUDOEPHED-DM, BROVANA, BUDESONIDE-FORMOTEROL FUMARATE, BUFFERED LIDOCAINE-EPINEPHRINE, BUPIVACAINE HCL-EPINEPHRINE, BUPIVACAINE-DEXAMETH-EPINEPHRN, BUPROPION HCL, BUPROPION HCL SR, BUPROPION XL, CARBOCAINE WITH NEO-COBEFRIN, CARVEDILOL, CARVEDILOL ER, CELEXA, CHLORDIAZEPOXIDE-AMITRIPTYLINE, CITALOPRAM HBR, CITANEST FORTE DENTAL, CLARINEX-D 12 HOUR, CLOMIPRAMINE HCL, COCAINE HCL, COMBIGAN, COMBIVENT RESPIMAT, CONCERTA, CONTRAVE, CONZIP, COREG, COREG CR, CORGARD, COSOPT, COSOPT PF, COTEMPLA XR-ODT, CYCLOBENZAPRINE HCL, CYCLOBENZAPRINE HCL ER, CYCLOPAK, CYCLOTENS, CYMBALTA, DAYTRANA, DESIPRAMINE HCL, DESOXYN, DESVENLAFAXINE ER, DESVENLAFAXINE SUCCINATE ER, DEXEDRINE, DEXMETHYLPHENIDATE HCL, DEXMETHYLPHENIDATE HCL ER, DEXTROAMPHETAMINE SULFATE, DEXTROAMPHETAMINE SULFATE ER, DEXTROAMPHETAMINE-AMPHET ER, DEXTROAMPHETAMINE-AMPHETAMINE, DIETHYLPROPION HCL, DIETHYLPROPION HCL ER, DOBUTAMINE HCL, DOBUTAMINE HCL-D5W, DOPAMINE HCL, DOPAMINE HCL IN 5% DEXTROSE, DORZOLAMIDE-TIMOLOL, DOXEPIN HCL, DRIZALMA SPRINKLE, DROXIDOPA, DUAKLIR PRESSAIR, DULERA, DULOXETINE HCL, DULOXICAINE, DYANAVEL XR, EFFEXOR XR, EMERPHED, EMSAM, EPHEDRINE HCL, EPHEDRINE SULFATE, EPHEDRINE SULFATE-0.9% NACL, EPHEDRINE SULFATE-NACL, EPINEPHRINE, EPINEPHRINE BITARTR-0.9% NACL, EPINEPHRINE BITARTRATE, EPINEPHRINE BITARTRATE-NACL, EPINEPHRINE CONVENIENCE KIT, EPINEPHRINE HCL-0.9% NACL, EPINEPHRINE HCL-D5W, EPINEPHRINE-0.9% NACL, EPINEPHRINE-D5W, EPINEPHRINE-NACL, ESCITALOPRAM OXALATE, EVEKEO, FETZIMA, FEXMID, FINTEPLA, FLUOXETINE DR, FLUOXETINE HCL, FLUTICASONE-SALMETEROL, FLUTICASONE-SALMETEROL HFA, FLUTICASONE-VILANTEROL, FLUVOXAMINE MALEATE, FLUVOXAMINE MALEATE ER, FOCALIN, FOCALIN XR, FORFIVO XL, FORMOTEROL FUMARATE, FURAZOLIDONE, GOPRELTO, HEMANGEOL, HYDROXYAMPHETAMINE HBR, IMIPRAMINE HCL, IMIPRAMINE PAMOATE, IMMPHENTIV, INDERAL LA, INDERAL XL, INGREZZA, INGREZZA INITIATION PK(TARDIV), INGREZZA SPRINKLE, INNOPRAN XL, IPRATROPIUM-ALBUTEROL, ISOMETHEPTENE MUCATE, ISOPROTERENOL HCL, ISOPROTERENOL HCL-0.9% NACL, ISTALOL, ISUPREL, JORNAY PM, LABETALOL HCL, LABETALOL HCL-WATER, LEVALBUTEROL CONCENTRATE, LEVALBUTEROL HCL, LEVALBUTEROL TARTRATE HFA, LEVOPHED, LEXAPRO, LIDOCAINE HCL-EPINEPHRINE, LIDOCAINE HCL-EPINEPHRINE-NACL, LIDOCAINE-EPINEPHRINE, LIGNOSPAN STANDARD, LINEZOLID, LINEZOLID-0.9% NACL, LINEZOLID-D5W, LISDEXAMFETAMINE DIMESYLATE, LOMAIRA, MARCAINE-EPINEPHRINE, MARPLAN, MATULANE, MB CAPS, ME-NAPHOS-MB-HYO 1, METADATE CD, METADATE ER, METAXALONE, METHAMPHETAMINE HCL, METHYLENE BLUE, METHYLIN, METHYLPHENIDATE, METHYLPHENIDATE ER, METHYLPHENIDATE ER (LA), METHYLPHENIDATE HCL, METHYLPHENIDATE HCL CD, METHYLPHENIDATE HCL ER (CD), MIDODRINE HCL, MIRABEGRON ER, MIRTAZAPINE, MIRTAZAPINE ANHYDROUS, MYDAYIS, MYRBETRIQ, NADOLOL, NARDIL, NEFAZODONE HCL, NOREPINEPHRINE BITAR-0.9% NACL, NOREPINEPHRINE BITARTRAT-WATER, NOREPINEPHRINE BITARTRATE, NOREPINEPHRINE BITARTRATE-D5W, NORPRAMIN, NORTHERA, NORTRIPTYLINE HCL, NUMBRINO, OLANZAPINE-FLUOXETINE HCL, ORABLOC, OXYMETAZOLINE HCL, PAMELOR, PARNATE, PAROXETINE CR, PAROXETINE ER, PAROXETINE HCL, PAROXETINE MESYLATE, PAXIL, PAXIL CR, PERFOROMIST, PERPHENAZINE-AMITRIPTYLINE, PHENDIMETRAZINE TARTRATE, PHENDIMETRAZINE TARTRATE ER, PHENELZINE SULFATE, PHENTERMINE HCL, PHENYLEPHRINE HCL, PHENYLEPHRINE HCL-0.9% NACL, PHENYLEPHRINE HCL-NACL, PHENYLEPHRINE HCL-WATER, PINDOLOL, PRISTIQ, PROAIR DIGIHALER, PROAIR RESPICLICK, PROCARBAZINE HCL, PROCENTRA, PROMETHAZINE VC, PROMETHAZINE-PHENYLEPHRINE HCL, PROPRANOLOL HCL, PROPRANOLOL HCL ER, PROPRANOLOL-HYDROCHLOROTHIAZID, PROTRIPTYLINE HCL, PROVAYBLUE, PROZAC, PSEUDOEPHEDRINE HCL, QDOLO, QELBREE, QSYMIA, QUILLICHEW ER, QUILLIVANT XR, R.E.C.K.(ROPIV-EPI-CLON-KETOR), RACEPINEPHRINE HCL, RALDESY, RASAGILINE MESYLATE, RELEXXII, REMERON, RESERPINE, RESPA A.R., REZIPRES, RITALIN, RITALIN LA, SAVELLA, SELEGILINE HCL, SENSORCAINE-EPINEPHRINE, SENSORCAINE-MPF EPINEPHRINE, SEPTOCAINE, SEREVENT DISKUS, SERTRALINE HCL, SILENOR, SOTALOL, SOTALOL AF, SOTALOL HCL, SOTYLIZE, STIOLTO RESPIMAT, STRIVERDI RESPIMAT, SYMBICORT, TERBUTALINE SULFATE, TETRABENAZINE, TETRAHYDROZOLINE HCL, TIMOLOL, TIMOLOL MALEATE, TIMOLOL-BIMATOPROST, TIMOLOL-BRIMONI-DORZOL-BIMATOP, TIMOLOL-BRIMONIDIN-DORZOLAMIDE, TIMOLOL-DORZOLAMIDE-BIMATOPRST, TIMOPTIC OCUDOSE, TRAMADOL HCL, TRAMADOL HCL ER, TRAMADOL HCL-ACETAMINOPHEN, TRANYLCYPROMINE SULFATE, TRAZODONE HCL, TRELEGY ELLIPTA, TRIMIPRAMINE MALEATE, TRINTELLIX, UMECLIDINIUM-VILANTEROL, URELLE, URETRON D-S, URIBEL TABS, URIMAR-T, URNEVA, URO-MP, URO-SP, UROGESIC-BLUE, URYL, VAZCULEP, VENLAFAXINE BESYLATE ER, VENLAFAXINE HCL, VENLAFAXINE HCL ER, VENTOLIN HFA, VIIBRYD, VILAZODONE HCL, VIVACAINE, VYVANSE, WELLBUTRIN SR, WELLBUTRIN XL, WIXELA INHUB, XADAGO, XELSTRYM, XENAZINE, XOPENEX HFA, XYLOCAINE DENTAL-EPINEPHRINE, XYLOCAINE WITH EPINEPHRINE, XYLOCAINE-MPF WITH EPINEPHRINE, XYLOMETAZOLINE HCL, YOHIMBINE HCL, ZELAPAR, ZENZEDI, ZOLOFT, ZYVOX

Drug Interaction

Drug Names

Radioactive Iodide/Agents that Affect Iodide

SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.

MECHANISM OF ACTION: Many compounds can affect iodide protein binding and alter iodide pharmacokinetics and pharmacodynamics.(1)

CLINICAL EFFECTS: Compounds that affect iodide pharmacokinetics and pharmacodynamics may impact the effectiveness of radioactive iodide.(1)

PREDISPOSING FACTORS: Compounds that affect iodide pharmacokinetics and pharmacodynamics are expected to have the most impact during therapy using radioactive iodide. Diagnostic procedures would be expected to be impacted less.

PATIENT MANAGEMENT: Discuss the use of agents that affect iodide pharmacokinetics and pharmacodynamics with the patient's oncologist.(1) Because indocyanine green contains sodium iodide, the iodine-binding capacity of thyroid tissue may be reduced for at least one week following administration. Do not perform radioactive iodine uptake studies for at least one week following administration of indocyanine green.(2)

The manufacturer of iopamidol states administration may interfere with thyroid uptake of radioactive iodine and decrease therapeutic and diagnostic efficacy. Avoid thyroid therapy or testing for up to 6 weeks post administration of iopamidol.(3)

DISCUSSION: Many agents interact with radioactive iodine. The average duration of effect is: anticoagulants - 1 week antihistamines - 1 week anti-thyroid drugs, e.g: carbimazole, methimazole, propylthiouracil - 3-5 days corticosteroids - 1 week iodide-containing medications, e.g:

amiodarone - 1-6 months expectorants - 2 weeks Lugol solution - 3 weeks saturated solution of potassium iodine - 3 weeks vitamins - 10-14 days iodide-containing X-ray contrast agents - up to 1 year lithium - 4 weeks phenylbutazone - 1-2 weeks sulfonamides - 1 week thyroid hormones (natural or synthetic), e.g.: thyroxine - 4 weeks tri-iodothyronine - 2 weeks tolbutamide - 1 week topical iodide - 1-9 months (1)

ADDAMEL N, ADTHYZA, ADVAIR DISKUS, ADVAIR HFA, AGAMREE, AIRDUO DIGIHALER, AIRDUO RESPICLICK, AIRSUPRA, ALKINDI SPRINKLE, ALVESCO, AMIODARONE HCL, AMIODARONE HCL-D5W, ARMONAIR DIGIHALER, ARMOUR THYROID, ARNUITY ELLIPTA, ASMANEX, ASMANEX HFA, AZELASTINE HCL, AZELASTINE-FLUTICASONE, AZULFIDINE, BACTRIM, BACTRIM DS, BECLOMETHASONE DIPROPIONATE, BETA 1, BETALOAN SUIK, BETAMETHASONE ACETATE MICRO, BETAMETHASONE ACETATE-SOD PHOS, BETAMETHASONE DIPROPIONATE, BETAMETHASONE SOD PHOS-ACETATE, BETAMETHASONE SOD PHOS-WATER, BETAMETHASONE SODIUM PHOSPHATE, BETAMETHASONE VALERATE, BREO ELLIPTA, BREYNA, BREZTRI AEROSPHERE, BROMFED DM, BROMPHENIRAMINE MALEATE, BROMPHENIRAMINE-PSEUDOEPHED-DM, BSP 0820, BUDESONIDE, BUDESONIDE DR, BUDESONIDE EC, BUDESONIDE ER, BUDESONIDE MICRONIZED, BUDESONIDE-FORMOTEROL FUMARATE, BUPIVACAINE-DEXAMETH-EPINEPHRN, CARBINOXAMINE MALEATE, CARBINOXAMINE MALEATE ER, CELESTONE, CETIRIZINE HCL, CHLORPHENIRAMINE MALEATE, CLARINEX, CLARINEX-D 12 HOUR, CLEMASTINE FUMARATE, CLEMASZ, CLIOQUINOL, CLOBETASOL PROPIONATE MICRO, CONRAY, CONRAY-30, CONRAY-43, CORTEF, CORTISONE ACETATE, CYPROHEPTADINE HCL, CYTOMEL, DATSCAN, DEFLAZACORT, DEPO-MEDROL, DESLORATADINE, DESONIDE MICRONIZED, DESOXIMETASONE, DEXABLISS, DEXAMETHASONE, DEXAMETHASONE ACETATE, DEXAMETHASONE ACETATE MICRO, DEXAMETHASONE INTENSOL, DEXAMETHASONE ISONICOTINATE, DEXAMETHASONE MICRONIZED, DEXAMETHASONE SOD PHOS-WATER, DEXAMETHASONE SODIUM PHOSPHATE, DEXAMETHASONE-0.9% NACL, DEXCHLORPHENIRAMINE MALEATE, DIATRIZOATE MEGLUMINE-SODIUM, DICLEGIS, DIPHEN, DIPHENHYDRAMINE HCL, DIPHENHYDRAMINE-0.9% NACL, DMT SUIK, DOUBLEDEX, DOXYLAMINE SUCC-PYRIDOXINE HCL, DULERA, DYMISTA, EMFLAZA, EOHILIA, ERMEZA, EUTHYROX, FEXOFENADINE HCL, FLUNISOLIDE, FLUOCINOLONE ACETONIDE, FLUOCINOLONE ACETONIDE MICRO, FLUOCINONIDE MICRONIZED, FLUTICASONE PROPIONATE, FLUTICASONE PROPIONATE HFA, FLUTICASONE PROPIONATE MICRO, FLUTICASONE-SALMETEROL, FLUTICASONE-SALMETEROL HFA, FLUTICASONE-VILANTEROL, GASTROGRAFIN, HEMADY, HEXATRIONE, HYDROCODONE-CHLORPHENIRAMNE ER, HYDROCORTISONE, HYDROCORTISONE SOD SUCCINATE, HYDROXYZINE HCL, HYDROXYZINE PAMOATE, IBUPROFEN-FAMOTIDINE, IC GREEN, IDOXURIDINE, INDOCYANINE GREEN, IODINE, IODIXANOL, IODOFORM, IODOPEN, IODOQUINOL, IOFLUPANE I-123, IOMERON 350, IOPAMIDOL, IOPANOIC ACID, ISOPROPAMIDE IODIDE, ISOVUE-200, ISOVUE-250, ISOVUE-300, ISOVUE-370, JANTOVEN, KARBINAL ER, KENALOG-10, KENALOG-40, KENALOG-80, LEVO-T, LEVOCETIRIZINE DIHYDROCHLORIDE, LEVOTHYROXINE SODIUM, LEVOXYL, LIDOCIDEX-I, LIOTHYRONINE SODIUM, LIPIODOL, LITHIUM CARBONATE, LITHIUM CARBONATE ER, LITHIUM CITRATE, LITHIUM CITRATE TETRAHYDRATE, LITHOBID, LORATADINE, LORATADINE MICRONIZED, LUGOL'S, MAS CARE-PAK, MD-GASTROVIEW, MEDROL, MEDROLOAN II SUIK, MEDROLOAN SUIK, METHIMAZOLE, METHYLPREDNISOLONE, METHYLPREDNISOLONE AC MICRO, METHYLPREDNISOLONE ACETATE, METHYLPREDNISOLONE SODIUM SUCC, MILLIPRED, MILLIPRED DP, MOMETASONE FUROATE, NEXTERONE, NIVA THYROID, NP THYROID, OLOPATADINE HCL, OMNARIS, OMNIPAQUE, OPTIRAY 240, OPTIRAY 300, OPTIRAY 320, OPTIRAY 350, ORAPRED ODT, ORTIKOS, OXILAN-350, PACERONE, PEDIAPRED, PEDITRACE, PHENERGAN, PHENIRAMINE MALEATE, PHENYLBUTAZONE, POTASSIUM IODIDE, POVIDONE IODINE, PREDNISOLONE, PREDNISOLONE SODIUM PHOS ODT, PREDNISOLONE SODIUM PHOSPHATE, PREDNISONE, PREDNISONE INTENSOL, PRO-C-DURE 5, PRO-C-DURE 6, PROMETHAZINE HCL, PROMETHAZINE HCL-0.9% NACL, PROMETHAZINE VC, PROMETHAZINE-CODEINE, PROMETHAZINE-DM, PROMETHAZINE-PHENYLEPHRINE HCL, PROPYLTHIOURACIL, PS1 ACIURGY PACK, PS2 ACIURGY PACK, PULMICORT, PULMICORT FLEXHALER, PYRILAMINE MALEATE, QNASL, QNASL CHILDREN, QUZYTTIR, QVAR REDIHALER, RAYOS, RENTHYROID, RESPA A.R., RYALTRIS, RYCLORA, RYVENT, SINOGRAFIN, SINUVA, SOLU-CORTEF, SOLU-MEDROL, SPY AGENT GREEN, SPY-MIS, SSKI, STRONG IODINE, SULFADIAZINE, SULFAMETHOXAZOLE-TRIMETHOPRIM, SULFASALAZINE, SULFASALAZINE DR, SULFATRIM, SYMBICORT, SYNTHROID, TAPERDEX, TARPEYO, THYMOL IODIDE, THYQUIDITY, THYROID, TICANASE, TIROSINT, TIROSINT-SOL, TRELEGY ELLIPTA, TRIAMCINOLONE, TRIAMCINOLONE ACETONIDE, TRIAMCINOLONE DIACETATE, TRIAMCINOLONE DIACETATE MICRO, TRILOAN II SUIK, TRILOAN SUIK, TUXARIN ER, UCERIS, ULTRAVIST, UNITHROID, VERIPRED 20, VISIPAQUE, WARFARIN SODIUM, WIXELA INHUB, XHANCE, ZCORT, ZETONNA, ZILRETTA

Iobenguane I 123/Agents that Affect Catecholamines

SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.

MECHANISM OF ACTION: Many compounds that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells.(1)

CLINICAL EFFECTS: Compounds that reduce catecholamine uptake or that deplete catecholamine stores may interfere with imaging completed with iobenguane.(1)

PREDISPOSING FACTORS: None determined.

PATIENT MANAGEMENT: Discuss the use of agents that affect catecholamines. Discontinue drugs that reduce catecholamine uptake or deplete catecholamine stores prior to imaging with iobenguane. Before imaging with iobenguane, discontinue agents that affect catecholamines for at least 5 biological half-lives, as clinically tolerated.(1)

DISCUSSION: Many agents may reduce catecholamine uptake or deplete catecholamine stores.(1) Examples include: - CNS stimulants or amphetamines (e.g. cocaine, methylphenidate, dextroamphetamine) - norepinephrine and dopamine reuptake inhibitors (e.g. phentermine) - norepinephrine and serotonin reuptake inhibitors (e.g. tramadol) - monoamine oxidase inhibitors (e.g. phenelzine, linezolid) - central monoamine depleting drugs (e.g. reserpine) - non-select beta adrenergic blocking drugs (e.g. labetalol) - alpha agonists or alpha/beta agonists (e.g. pseudoephedrine, phenylephrine, ephedrine, phenylpropanolamine, naphazoline) - tricyclic antidepressants or norepinephrine reuptake inhibitors (e.g. amitriptyline, bupropion, duloxetine, mirtazapine, venlafaxine) - botanicals that may inhibit reuptake of norepinephrine, serotonin or dopamine (e.g. ephedra, ma huang, St. John's Wort, yohimbine)

ADDERALL, ADDERALL XR, ADIPEX-P, ADRENALIN, ADVAIR DISKUS, ADVAIR HFA, ADZENYS XR-ODT, AIRDUO DIGIHALER, AIRDUO RESPICLICK, AIRSUPRA, AKOVAZ, ALBUTEROL SULFATE, ALBUTEROL SULFATE HFA, AMITRIPTYLINE HCL, AMOXAPINE, AMPHETAMINE SULFATE, AMRIX, ANAFRANIL, ANORO ELLIPTA, APLENZIN, APTENSIO XR, ARFORMOTEROL TARTRATE, ARTICADENT DENTAL, ARTICAINE-EPINEPHRINE, ARTICAINE-EPINEPHRINE BIT, AUSTEDO, AUSTEDO XR, AUSTEDO XR TITRATION KT(WK1-4), AUVELITY, AZILECT, AZSTARYS, BENACTYZINE HCL, BENZPHETAMINE HCL, BETAPACE, BETAPACE AF, BETIMOL, BEVESPI AEROSPHERE, BIORPHEN, BREO ELLIPTA, BREYNA, BREZTRI AEROSPHERE, BRIMONIDINE TARTRATE-TIMOLOL, BROMFED DM, BROMPHENIRAMINE-PSEUDOEPHED-DM, BROVANA, BUDESONIDE-FORMOTEROL FUMARATE, BUFFERED LIDOCAINE-EPINEPHRINE, BUPIVACAINE HCL-EPINEPHRINE, BUPIVACAINE-DEXAMETH-EPINEPHRN, BUPROPION HCL, BUPROPION HCL SR, BUPROPION XL, CARBOCAINE WITH NEO-COBEFRIN, CARVEDILOL, CARVEDILOL ER, CELEXA, CHLORDIAZEPOXIDE-AMITRIPTYLINE, CITALOPRAM HBR, CITANEST FORTE DENTAL, CLARINEX-D 12 HOUR, CLOMIPRAMINE HCL, COCAINE HCL, COMBIGAN, COMBIVENT RESPIMAT, CONCERTA, CONTRAVE, CONZIP, COREG, COREG CR, CORGARD, COSOPT, COSOPT PF, COTEMPLA XR-ODT, CYCLOBENZAPRINE HCL, CYCLOBENZAPRINE HCL ER, CYCLOPAK, CYCLOTENS, CYMBALTA, DAYTRANA, DESIPRAMINE HCL, DESOXYN, DESVENLAFAXINE ER, DESVENLAFAXINE SUCCINATE ER, DEXEDRINE, DEXMETHYLPHENIDATE HCL, DEXMETHYLPHENIDATE HCL ER, DEXTROAMPHETAMINE SULFATE, DEXTROAMPHETAMINE SULFATE ER, DEXTROAMPHETAMINE-AMPHET ER, DEXTROAMPHETAMINE-AMPHETAMINE, DIETHYLPROPION HCL, DIETHYLPROPION HCL ER, DOBUTAMINE HCL, DOBUTAMINE HCL-D5W, DOPAMINE HCL, DOPAMINE HCL IN 5% DEXTROSE, DORZOLAMIDE-TIMOLOL, DOXEPIN HCL, DRIZALMA SPRINKLE, DROXIDOPA, DUAKLIR PRESSAIR, DULERA, DULOXETINE HCL, DULOXICAINE, DYANAVEL XR, EFFEXOR XR, EMERPHED, EMSAM, EPHEDRINE HCL, EPHEDRINE SULFATE, EPHEDRINE SULFATE-0.9% NACL, EPHEDRINE SULFATE-NACL, EPINEPHRINE, EPINEPHRINE BITARTR-0.9% NACL, EPINEPHRINE BITARTRATE, EPINEPHRINE BITARTRATE-NACL, EPINEPHRINE CONVENIENCE KIT, EPINEPHRINE HCL-0.9% NACL, EPINEPHRINE HCL-D5W, EPINEPHRINE-0.9% NACL, EPINEPHRINE-D5W, EPINEPHRINE-NACL, ESCITALOPRAM OXALATE, EVEKEO, FETZIMA, FEXMID, FINTEPLA, FLUOXETINE DR, FLUOXETINE HCL, FLUTICASONE-SALMETEROL, FLUTICASONE-SALMETEROL HFA, FLUTICASONE-VILANTEROL, FLUVOXAMINE MALEATE, FLUVOXAMINE MALEATE ER, FOCALIN, FOCALIN XR, FORFIVO XL, FORMOTEROL FUMARATE, FURAZOLIDONE, GOPRELTO, HEMANGEOL, HYDROXYAMPHETAMINE HBR, IMIPRAMINE HCL, IMIPRAMINE PAMOATE, IMMPHENTIV, INDERAL LA, INDERAL XL, INGREZZA, INGREZZA INITIATION PK(TARDIV), INGREZZA SPRINKLE, INNOPRAN XL, IPRATROPIUM-ALBUTEROL, ISOMETHEPTENE MUCATE, ISOPROTERENOL HCL, ISOPROTERENOL HCL-0.9% NACL, ISTALOL, ISUPREL, JORNAY PM, LABETALOL HCL, LABETALOL HCL-WATER, LEVALBUTEROL CONCENTRATE, LEVALBUTEROL HCL, LEVALBUTEROL TARTRATE HFA, LEVOPHED, LEXAPRO, LIDOCAINE HCL-EPINEPHRINE, LIDOCAINE HCL-EPINEPHRINE-NACL, LIDOCAINE-EPINEPHRINE, LIGNOSPAN STANDARD, LINEZOLID, LINEZOLID-0.9% NACL, LINEZOLID-D5W, LISDEXAMFETAMINE DIMESYLATE, LOMAIRA, MARCAINE-EPINEPHRINE, MARPLAN, MATULANE, MB CAPS, ME-NAPHOS-MB-HYO 1, METADATE CD, METADATE ER, METAXALONE, METHAMPHETAMINE HCL, METHYLENE BLUE, METHYLIN, METHYLPHENIDATE, METHYLPHENIDATE ER, METHYLPHENIDATE ER (LA), METHYLPHENIDATE HCL, METHYLPHENIDATE HCL CD, METHYLPHENIDATE HCL ER (CD), MIDODRINE HCL, MIRABEGRON ER, MIRTAZAPINE, MIRTAZAPINE ANHYDROUS, MYDAYIS, MYRBETRIQ, NADOLOL, NARDIL, NEFAZODONE HCL, NOREPINEPHRINE BITAR-0.9% NACL, NOREPINEPHRINE BITARTRAT-WATER, NOREPINEPHRINE BITARTRATE, NOREPINEPHRINE BITARTRATE-D5W, NORPRAMIN, NORTHERA, NORTRIPTYLINE HCL, NUMBRINO, OLANZAPINE-FLUOXETINE HCL, ORABLOC, OXYMETAZOLINE HCL, PAMELOR, PARNATE, PAROXETINE CR, PAROXETINE ER, PAROXETINE HCL, PAROXETINE MESYLATE, PAXIL, PAXIL CR, PERFOROMIST, PERPHENAZINE-AMITRIPTYLINE, PHENDIMETRAZINE TARTRATE, PHENDIMETRAZINE TARTRATE ER, PHENELZINE SULFATE, PHENTERMINE HCL, PHENYLEPHRINE HCL, PHENYLEPHRINE HCL-0.9% NACL, PHENYLEPHRINE HCL-NACL, PHENYLEPHRINE HCL-WATER, PINDOLOL, PRISTIQ, PROAIR DIGIHALER, PROAIR RESPICLICK, PROCARBAZINE HCL, PROCENTRA, PROMETHAZINE VC, PROMETHAZINE-PHENYLEPHRINE HCL, PROPRANOLOL HCL, PROPRANOLOL HCL ER, PROPRANOLOL-HYDROCHLOROTHIAZID, PROTRIPTYLINE HCL, PROVAYBLUE, PROZAC, PSEUDOEPHEDRINE HCL, QDOLO, QELBREE, QSYMIA, QUILLICHEW ER, QUILLIVANT XR, R.E.C.K.(ROPIV-EPI-CLON-KETOR), RACEPINEPHRINE HCL, RALDESY, RASAGILINE MESYLATE, RELEXXII, REMERON, RESERPINE, RESPA A.R., REZIPRES, RITALIN, RITALIN LA, SAVELLA, SELEGILINE HCL, SENSORCAINE-EPINEPHRINE, SENSORCAINE-MPF EPINEPHRINE, SEPTOCAINE, SEREVENT DISKUS, SERTRALINE HCL, SILENOR, SOTALOL, SOTALOL AF, SOTALOL HCL, SOTYLIZE, STIOLTO RESPIMAT, STRIVERDI RESPIMAT, SYMBICORT, TERBUTALINE SULFATE, TETRABENAZINE, TETRAHYDROZOLINE HCL, TIMOLOL, TIMOLOL MALEATE, TIMOLOL-BIMATOPROST, TIMOLOL-BRIMONI-DORZOL-BIMATOP, TIMOLOL-BRIMONIDIN-DORZOLAMIDE, TIMOLOL-DORZOLAMIDE-BIMATOPRST, TIMOPTIC OCUDOSE, TRAMADOL HCL, TRAMADOL HCL ER, TRAMADOL HCL-ACETAMINOPHEN, TRANYLCYPROMINE SULFATE, TRAZODONE HCL, TRELEGY ELLIPTA, TRIMIPRAMINE MALEATE, TRINTELLIX, UMECLIDINIUM-VILANTEROL, URELLE, URETRON D-S, URIBEL TABS, URIMAR-T, URNEVA, URO-MP, URO-SP, UROGESIC-BLUE, URYL, VAZCULEP, VENLAFAXINE BESYLATE ER, VENLAFAXINE HCL, VENLAFAXINE HCL ER, VENTOLIN HFA, VIIBRYD, VILAZODONE HCL, VIVACAINE, VYVANSE, WELLBUTRIN SR, WELLBUTRIN XL, WIXELA INHUB, XADAGO, XELSTRYM, XENAZINE, XOPENEX HFA, XYLOCAINE DENTAL-EPINEPHRINE, XYLOCAINE WITH EPINEPHRINE, XYLOCAINE-MPF WITH EPINEPHRINE, XYLOMETAZOLINE HCL, YOHIMBINE HCL, ZELAPAR, ZENZEDI, ZOLOFT, ZYVOX

There are 0 moderate interactions.

The following contraindication information is available for ADREVIEW (iobenguane sulfate i-123):

Overview
Contraindicated
Severe
Moderate

Drug contraindication overview.

No enhanced Contraindications information available for this drug.

There are 1 contraindications. Absolute contraindication.

Contraindication List
Lactation

There are 1 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Severe renal impairment

There are 1 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Hypertension

The following adverse reaction information is available for ADREVIEW (iobenguane sulfate i-123):

Overview
Severe
Less Severe

Adverse reaction overview.

No enhanced Common Adverse Effects information available for this drug.

There are 3 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Anaphylaxis Hypersensitivity drug reaction Hypertension

There are 6 less severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Dizziness Flushing Hematoma Injection site sequelae Pruritus of skin Skin rash

The following precautions are available for ADREVIEW (iobenguane sulfate i-123):

Pediatric
Pregnant
Lactation
Geriatric

No enhanced Pediatric Use information available for this drug.

Contraindicated

None

Severe Precaution

None

Management or Monitoring Precaution

None

No enhanced Pregnancy information available for this drug.

No enhanced Lactation information available for this drug.

No enhanced Geriatric Use information available for this drug.